• SkinCeuticals P-TIOX
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SkinCeuticals

P-TIOX

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Softer looking expression lines and smoother, more radiant skin.

The lines from years of laughing, squinting and concentrating are starting to stay put, and you want them to look softer without changing how your face moves. Some of them sit where injections usually are not used, like the folds around your mouth and the lines under your eyes.

P-TIOX visibly softens nine types of expression lines and leaves skin smoother and more radiant within a week. It pairs a hexapeptide and a dipeptide with 5% polyhydroxy acid, 5% niacinamide and 1% laminaria extract, a combination SkinCeuticals found works better than peptides alone. It is physician tested alongside neurotoxin injections and works on its own too.

Who It Is For

Anyone with expression lines on the forehead, between the brows, around the eyes or around the mouth, and anyone who wants smoother, more radiant skin. Suitable for all skin types and tones, including sensitive skin.

Acne Safe

What You Will See, and When

In SkinCeuticals' clinical testing, skin looked smoother and more radiant, with more refined looking pores, in one week. By twelve weeks the look of nine types of expression lines was reduced, including smile lines, crow's feet, forehead and frown lines, marionette lines and lines under the eyes. Results build with steady twice daily use.

How to Use

Use it morning and night on dry skin. Dispense four to six drops into your palm, dab onto forehead, cheeks and chin, then blend in. In the morning it goes on after your vitamin C serum, followed by moisturizer, and sunscreen goes on last.

The Science

Expression lines form where facial muscles contract over and over, every time you smile, squint or frown. As skin gradually makes less collagen, elastin and hyaluronic acid, those lines stay visible even when your face is at rest.

P-TIOX pairs acetyl hexapeptide-8 and dipeptide diaminobutyroyl benzylamide diacetate, two peptides studied for softening the look of these lines. SkinCeuticals amplified them with polyhydroxy acid, a gentle exfoliant that smooths texture and boosts radiance; niacinamide, which supports the moisture barrier and evens the look of tone; and laminaria, a brown seaweed extract that hydrates and soothes. In the brand's testing, the full formula outperformed peptides alone.

Used alongside neurotoxin injections, it softened the look of five types of lines in areas that were not injected within one month, compared with a control group.

Questions

Can I use it if I get injections?Yes. It was physician tested alongside neurotoxin injections and helps the look of lines in areas that are not injected.
Can I use it with retinol?Yes. SkinCeuticals formulated it to work alongside retinol.
What is it free of?Fragrance, silicone, parabens and dyes. It is also TSA approved, so it can travel with you.

Why a Routine Made for You Works Better

General advice is written for everyone, so it has to assume nothing about you. It can tell you what is safe. It cannot tell you what will work for your skin.

Skin changes when it is challenged just enough, then given time to recover and adapt. That amount is different for every person, and it moves as your skin gets stronger. Ask too much and your skin spends its energy recovering instead of improving. Ask too little and nothing changes. Finding that point for you, and moving it at the right time, is where results come from.

Where that point sits depends on:

  • Your skin: its history, how it reacts, and what it is doing today
  • Your health: hormones, medications, pregnancy and any condition that changes how skin behaves
  • Your lifestyle: sleep, stress, diet, sun, exercise and climate
  • Your routine: what you use now, and what has and has not worked before
  • Your goals: what you most want to change
  • Your expectations and timeline: how soon you want to see change, and what is realistic for your skin
  • Your consistency: how much time and how many steps you will keep up with, because the best routine is the one you actually do
  • Your treatments: what you have had and what you have planned

A skin therapist weighs all of this, builds a routine you can keep, and adjusts it as your skin responds. That is why we guarantee our products when they are part of a routine designed by one of our skin therapists. If you have been reading general advice, bring your questions. We will help you sort out what applies to you and what does not.

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Key Ingredients

Peptide complex (hexapeptide and dipeptide)Softens the look of expression lines
Polyhydroxy acid (5%)Gently smooths texture and boosts radiance
Niacinamide (5%)Supports the moisture barrier and evens the look of tone
Laminaria extract (1%)Hydrates and soothes
Full Ingredient List

Aqua / Water / Eau, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8

References

1. SkinCeuticals product information and clinical data (skinceuticals.com): 1 week, smoothness, pores and radiance; 12 weeks, nine types of expression lines; 1 month post injection, five wrinkle types in areas not injected, compared with control.
2. Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

    SkinCeuticals P-TIOX

    Frequently Bought Together

    Your Complete Routine

    Expression lines, fine lines or uneven texture? Try this routine.