{"product_id":"dermal-repair-cream-design-test-do-not-publish","title":"Dermal Repair Cream (TEST PAGE)","description":"\u003cdiv style=\"max-width:720px;color:#1A1A1A;font-size:16px;line-height:1.65;\"\u003e\n\u003cp style=\"font-size:20px;line-height:1.42;margin:0 0 15px;\"\u003eYour face goes red and takes forever to calm down. Every breakout leaves a brown mark that is still there months later. Your skin reacts to things that never used to bother it. And you have spent real money on moisturizers that felt lovely and changed none of it.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eThey are not four problems. They share a cause.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eYour skin makes a molecule called heparan sulfate, and it does two jobs. It holds water inside the tissue, and it carries the repair signal, holding growth factors in position long enough to reach the cells that need them. You make less of it every year, and ultraviolet light speeds that up by switching on the enzyme that breaks it down. Sun exposed skin shows the loss. Sun protected skin on the same person does not.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eThat is why skin that is perfectly well moisturized can still stay red and hold onto marks. Hydration on the surface does not restore the signal underneath. It is also why the same underlying problem shows up as redness in one person, pigment in another, and reactivity in a third.\u003c\/p\u003e\n\u003ch2 style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;font-weight:400;margin:30px 0 11px;\"\u003eWhat this does about it\u003c\/h2\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eHeparan sulfate itself is far too large to get through skin, so for decades it was a good idea with no way in. Senté built HSA, a low molecular weight analog small enough to penetrate, and it does, within 48 hours of once daily use.\u003c\/p\u003e\n\u003cul style=\"margin:0 0 18px;padding-left:20px;\"\u003e\n\u003cli style=\"margin-bottom:8px;\"\u003e\n\u003cstrong\u003eCalms redness\u003c\/strong\u003e by binding LL-37, the peptide that sets off the inflammatory cascade behind flushing and rosacea.\u003c\/li\u003e\n\u003cli style=\"margin-bottom:8px;\"\u003e\n\u003cstrong\u003eHolds hydration in the skin\u003c\/strong\u003e rather than on it.\u003c\/li\u003e\n\u003cli style=\"margin-bottom:8px;\"\u003e\n\u003cstrong\u003eWorks on the inflammation that drives pigment,\u003c\/strong\u003e which is what leaves a mark after a breakout.\u003c\/li\u003e\n\u003cli style=\"margin-bottom:8px;\"\u003e\n\u003cstrong\u003eSupports recovery,\u003c\/strong\u003e which is why it is safe to use post procedure.\u003c\/li\u003e\n\u003cli style=\"margin-bottom:8px;\"\u003e\u003cstrong\u003eSuitable for acne prone skin.\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;font-weight:400;margin:30px 0 11px;\"\u003eWhat you will see, and when\u003c\/h2\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eIn a randomized, double blind trial, redness significantly improved over eight weeks, and pulsed dye laser was better tolerated than the laser alone. Applied around the eyes, discoloration and fine lines improved by week two and were still improving at week twelve.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eGive it two weeks before you look for change, and twelve before you decide.\u003c\/p\u003e\n\u003ch2 style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;font-weight:400;margin:30px 0 11px;\"\u003eKey ingredients\u003c\/h2\u003e\n\u003cdiv style=\"border-top:1px solid #E7E1EB;\"\u003e\n\u003cdiv style=\"padding:12px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15.5px;\"\u003eHSA\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eSenté's low molecular weight analog of heparan sulfate\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:12px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15.5px;\"\u003eGreen tea leaf extract\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eAntioxidant, calms without irritating\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:12px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15.5px;\"\u003eSodium hyaluronate\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eSurface hydration\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:12px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15.5px;\"\u003eArgan kernel oil and vitamin E\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eLipids and a fat soluble antioxidant\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;font-weight:400;margin:30px 0 11px;\"\u003eHow to use\u003c\/h2\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eTwo to five pumps in the morning, five to eight at night, after your serums. Adjust for how dry you are. Warm it between your fingertips and press it in.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 14px;\"\u003eMoisturizer goes before sunscreen, never after.\u003c\/p\u003e\n\u003cdiv style=\"background:#F3EFF5;padding:22px 26px;margin:26px 0;\"\u003e\n\u003cp style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;margin:0 0 10px;\"\u003eWhy we carry it\u003c\/p\u003e\n\u003cp style=\"margin:0;font-size:16px;\"\u003eMost moisturizers pick a lane. This one holds hydration and calms inflammation at the same time, which is why it suits almost any skin and almost any routine rather than one skin type. It is also what we use post procedure, when the priority is recovery rather than actives.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdetails style=\"border-top:1px solid #D4C8DC;padding:15px 0;\"\u003e\u003csummary style=\"cursor:pointer;font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;\"\u003eThe science\u003c\/summary\u003e\u003cp style=\"margin:13px 0 0;font-size:14.5px;line-height:1.72;\"\u003eHeparan sulfate is a sulfated glycosaminoglycan found on cell surfaces and throughout the extracellular matrix. It acts as a co-receptor for effectively every growth factor the skin uses, FGF, EGF, VEGF, TGF-beta and HGF among them, presenting them to their high affinity receptors and protecting them from proteolytic degradation.\u003c\/p\u003e\n\u003cp style=\"margin:13px 0 0;font-size:14.5px;line-height:1.72;\"\u003eUltraviolet B exposure activates heparanase, the enzyme that cleaves heparan sulfate. As it degrades in the basement membrane, that membrane loses its binding capacity for VEGF and FGF, and growth factor signalling across the dermal epidermal junction falls away. Degradation is observed in sun exposed skin and not in sun protected skin from the same subject, which is one of the mechanisms of photoaging.\u003c\/p\u003e\n\u003cp style=\"margin:13px 0 0;font-size:14.5px;line-height:1.72;\"\u003eIn rosacea, the cathelicidin peptide LL-37 activates the NLRP3 inflammasome and drives the inflammatory cascade. LL-37 is inhibited by binding to cell surface heparan sulfate. In human epidermal keratinocytes, HSA reduced LL-37 toxicity and decreased IL-8 release.\u003c\/p\u003e\n\u003cp style=\"margin:13px 0 0;font-size:14.5px;line-height:1.72;\"\u003eNative heparan sulfate is large and highly polar and cannot penetrate the skin. The low molecular weight analog does, within 48 hours of once daily topical application.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-top:1px solid #D4C8DC;padding:15px 0;\"\u003e\u003csummary style=\"cursor:pointer;font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;\"\u003eFull ingredient list and format\u003c\/summary\u003e\u003cp style=\"margin:13px 0 0;font-size:13.5px;color:#666666;line-height:1.72;\"\u003eAqua\/Water\/Eau, Caprylic\/Capric Triglyceride, C12-15 Alkyl Benzoate, Glycerin, Cetearyl Alcohol, Argania Spinosa Kernel Oil, Heparan Sulfate, Acetyl Glucosamine, Ethylhexyl Palmitate, Glyceryl Stearate, PEG-100 Stearate, Potassium Cetyl Phosphate, Cyclopentasiloxane, Dimethicone, Butylene Glycol, Tocopheryl Acetate, Tocopherol, Sodium Hyaluronate, Camellia Sinensis Leaf Extract, Chenopodium Quinoa Seed Extract, Acrylates\/C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, Sodium Benzoate, Sorbic Acid, Potassium Sorbate, 1,2-Hexanediol, Caprylyl Glycol, Phenoxyethanol, Disodium EDTA.\u003c\/p\u003e\n\u003cp style=\"margin:13px 0 0;font-size:13.5px;color:#666666;line-height:1.72;\"\u003ePump bottle. Medium weight, absorbs without residue. Fragrance free. Approximate pH 5.5. Sits under makeup and under sunscreen.\u003c\/p\u003e\u003c\/details\u003e\u003cdetails style=\"border-top:1px solid #D4C8DC;border-bottom:1px solid #D4C8DC;padding:15px 0;margin-bottom:24px;\"\u003e\u003csummary style=\"cursor:pointer;font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;\"\u003eReferences\u003c\/summary\u003e\u003cp style=\"margin:13px 0 0;font-size:13.5px;color:#666666;line-height:1.6;\"\u003e1. George R, Gallo RL, Cohen JL, et al. Reduction of erythema in moderate-severe rosacea by a low molecular weight Heparan Sulfate Analog (HSA). J Drugs Dermatol. 2023;22(6):546-553.\u003cbr\u003e2. Iriyama S, et al. Activation of heparanase by ultraviolet B irradiation leads to functional loss of basement membrane at the dermal-epidermal junction in human skin. Arch Dermatol Res. 2011;303(4):253-261.\u003cbr\u003e3. Bucay V, Gold MH, Andriessen A. Low molecular weight heparan sulfate containing facial skin care for reducing inflammation and restoring aged-skin homeostasis. J Cosmet Dermatol. 2020;19(8):1851-1856.\u003cbr\u003e4. Bernfield M, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999;68:729-777.\u003c\/p\u003e\u003c\/details\u003e\u003ch2 style=\"font-size:11px;letter-spacing:2.4px;text-transform:uppercase;color:#9B8AA5;font-weight:400;margin:30px 0 11px;\"\u003eQuestions\u003c\/h2\u003e\n\u003cdiv style=\"border-top:1px solid #E7E1EB;\"\u003e\n\u003cdiv style=\"padding:14px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15px;\"\u003eWhere does it go in my routine?\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eAfter your serums, before sunscreen. Sunscreen is always the last morning step, and eye cream is last at night.\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:14px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15px;\"\u003eCan I use it with a retinoid?\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eYes. Apply your retinoid first and this on top.\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:14px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15px;\"\u003eIs it safe while pregnant or nursing?\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eWe recommend checking with your healthcare provider.\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"padding:14px 0;border-bottom:1px solid #E7E1EB;\"\u003e\n\u003cb style=\"display:block;font-size:15px;\"\u003eShipping and returns\u003c\/b\u003e\u003cspan style=\"font-size:14.5px;color:#666666;\"\u003eShips from Seattle in 1 to 2 business days. Returns accepted within 30 days, unused or gently used.\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Senté","offers":[{"title":"Default Title","offer_id":49634242953431,"sku":"52350","price":167.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0321\/9206\/9768\/products\/Untitleddesign-24.png?v=1617732309","url":"https:\/\/shop.sapienskinseattle.com\/products\/dermal-repair-cream-design-test-do-not-publish","provider":"Sapien Skin + Beauty","version":"1.0","type":"link"}